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A , Heatmap of top 100 DEGs in P1_L vs other lesional skin (P2-P5 L) (padj < 0.05, log2FC > ±0.25; Wilcoxon) B , UMAP of cytotoxicity signature in lesional skin (P1-P5). Top: composite score; right/below: four cytotoxic effector genes. C , Cytotoxicity score across all patients (Wilcoxon; P1_L vs P2-P5 L). D , Spatial map of cytotoxicity score in P1_L (middle), underlying H&E histology (left panel) and zoomed view of a representative area showing individual gene expression for selected genes (right). E, Cell type deconvolution (pie charts) of representative area (from D ). F , Fold enrichment of topics in high (≥Q3, top 25%) vs low (<Q3, bottom 75%) cytotoxic regions of P1_L (Wilcoxon with Bejamini Hochberg correction; red dotted line: log2FC =1). G , Correlation between total cytotoxic cell abundance (Tcyto, Cytomono, M1_mac, Neuts) and cytotoxicity score. Points coloured by patient; P1_L (95% CI); ρ = Spearman’s rank. H , Organised_immune topic proportion in P1 L vs P2-P5 L (Wilcoxon). I , Organized immune topic distribution in P1_L across full tissue (left), magnified region (top right), and other topics as pie charts (bottom). J , tertiary lymphoid structures (TLS) hallmark gene expression in representative area from ( I) . K , Multiplex immunofluorescence (IF)of two putative TLS from P1_L showing CD3E+ T cells (top) and <t>CD20+</t> B cells (bottom) in magnified regions. Scale bar, 20µm. **p < 0.01, ****p < 0.0001
Cd20, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cd20+antibody+%28igel/med_rxiv__64898__2026__02__04__26345554-239-7-10?v=Novus+Biologicals
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macrophages nbp2 34587af647  (Novus Biologicals)
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A , Heatmap of top 100 DEGs in P1_L vs other lesional skin (P2-P5 L) (padj < 0.05, log2FC > ±0.25; Wilcoxon) B , UMAP of cytotoxicity signature in lesional skin (P1-P5). Top: composite score; right/below: four cytotoxic effector genes. C , Cytotoxicity score across all patients (Wilcoxon; P1_L vs P2-P5 L). D , Spatial map of cytotoxicity score in P1_L (middle), underlying H&E histology (left panel) and zoomed view of a representative area showing individual gene expression for selected genes (right). E, Cell type deconvolution (pie charts) of representative area (from D ). F , Fold enrichment of topics in high (≥Q3, top 25%) vs low (<Q3, bottom 75%) cytotoxic regions of P1_L (Wilcoxon with Bejamini Hochberg correction; red dotted line: log2FC =1). G , Correlation between total cytotoxic cell abundance (Tcyto, Cytomono, M1_mac, Neuts) and cytotoxicity score. Points coloured by patient; P1_L (95% CI); ρ = Spearman’s rank. H , Organised_immune topic proportion in P1 L vs P2-P5 L (Wilcoxon). I , Organized immune topic distribution in P1_L across full tissue (left), magnified region (top right), and other topics as pie charts (bottom). J , tertiary lymphoid structures (TLS) hallmark gene expression in representative area from ( I) . K , Multiplex immunofluorescence (IF)of two putative TLS from P1_L showing CD3E+ T cells (top) and <t>CD20+</t> B cells (bottom) in magnified regions. Scale bar, 20µm. **p < 0.01, ****p < 0.0001
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anti cd20  (Novus Biologicals)
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A , Heatmap of top 100 DEGs in P1_L vs other lesional skin (P2-P5 L) (padj < 0.05, log2FC > ±0.25; Wilcoxon) B , UMAP of cytotoxicity signature in lesional skin (P1-P5). Top: composite score; right/below: four cytotoxic effector genes. C , Cytotoxicity score across all patients (Wilcoxon; P1_L vs P2-P5 L). D , Spatial map of cytotoxicity score in P1_L (middle), underlying H&E histology (left panel) and zoomed view of a representative area showing individual gene expression for selected genes (right). E, Cell type deconvolution (pie charts) of representative area (from D ). F , Fold enrichment of topics in high (≥Q3, top 25%) vs low (<Q3, bottom 75%) cytotoxic regions of P1_L (Wilcoxon with Bejamini Hochberg correction; red dotted line: log2FC =1). G , Correlation between total cytotoxic cell abundance (Tcyto, Cytomono, M1_mac, Neuts) and cytotoxicity score. Points coloured by patient; P1_L (95% CI); ρ = Spearman’s rank. H , Organised_immune topic proportion in P1 L vs P2-P5 L (Wilcoxon). I , Organized immune topic distribution in P1_L across full tissue (left), magnified region (top right), and other topics as pie charts (bottom). J , tertiary lymphoid structures (TLS) hallmark gene expression in representative area from ( I) . K , Multiplex immunofluorescence (IF)of two putative TLS from P1_L showing CD3E+ T cells (top) and <t>CD20+</t> B cells (bottom) in magnified regions. Scale bar, 20µm. **p < 0.01, ****p < 0.0001
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Average 93 stars, based on 1 article reviews
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nbp2 44745  (Novus Biologicals)
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Novus Biologicals nbp2 44745
A , Heatmap of top 100 DEGs in P1_L vs other lesional skin (P2-P5 L) (padj < 0.05, log2FC > ±0.25; Wilcoxon) B , UMAP of cytotoxicity signature in lesional skin (P1-P5). Top: composite score; right/below: four cytotoxic effector genes. C , Cytotoxicity score across all patients (Wilcoxon; P1_L vs P2-P5 L). D , Spatial map of cytotoxicity score in P1_L (middle), underlying H&E histology (left panel) and zoomed view of a representative area showing individual gene expression for selected genes (right). E, Cell type deconvolution (pie charts) of representative area (from D ). F , Fold enrichment of topics in high (≥Q3, top 25%) vs low (<Q3, bottom 75%) cytotoxic regions of P1_L (Wilcoxon with Bejamini Hochberg correction; red dotted line: log2FC =1). G , Correlation between total cytotoxic cell abundance (Tcyto, Cytomono, M1_mac, Neuts) and cytotoxicity score. Points coloured by patient; P1_L (95% CI); ρ = Spearman’s rank. H , Organised_immune topic proportion in P1 L vs P2-P5 L (Wilcoxon). I , Organized immune topic distribution in P1_L across full tissue (left), magnified region (top right), and other topics as pie charts (bottom). J , tertiary lymphoid structures (TLS) hallmark gene expression in representative area from ( I) . K , Multiplex immunofluorescence (IF)of two putative TLS from P1_L showing CD3E+ T cells (top) and <t>CD20+</t> B cells (bottom) in magnified regions. Scale bar, 20µm. **p < 0.01, ****p < 0.0001
Nbp2 44745, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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nbp2 44745 - by Bioz Stars, 2026-07
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Novus Biologicals nbp2 47840af647 rrid ab 3313026
A , Heatmap of top 100 DEGs in P1_L vs other lesional skin (P2-P5 L) (padj < 0.05, log2FC > ±0.25; Wilcoxon) B , UMAP of cytotoxicity signature in lesional skin (P1-P5). Top: composite score; right/below: four cytotoxic effector genes. C , Cytotoxicity score across all patients (Wilcoxon; P1_L vs P2-P5 L). D , Spatial map of cytotoxicity score in P1_L (middle), underlying H&E histology (left panel) and zoomed view of a representative area showing individual gene expression for selected genes (right). E, Cell type deconvolution (pie charts) of representative area (from D ). F , Fold enrichment of topics in high (≥Q3, top 25%) vs low (<Q3, bottom 75%) cytotoxic regions of P1_L (Wilcoxon with Bejamini Hochberg correction; red dotted line: log2FC =1). G , Correlation between total cytotoxic cell abundance (Tcyto, Cytomono, M1_mac, Neuts) and cytotoxicity score. Points coloured by patient; P1_L (95% CI); ρ = Spearman’s rank. H , Organised_immune topic proportion in P1 L vs P2-P5 L (Wilcoxon). I , Organized immune topic distribution in P1_L across full tissue (left), magnified region (top right), and other topics as pie charts (bottom). J , tertiary lymphoid structures (TLS) hallmark gene expression in representative area from ( I) . K , Multiplex immunofluorescence (IF)of two putative TLS from P1_L showing CD3E+ T cells (top) and <t>CD20+</t> B cells (bottom) in magnified regions. Scale bar, 20µm. **p < 0.01, ****p < 0.0001
Nbp2 47840af647 Rrid Ab 3313026, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cd20+antibody+%28igel/pmc12281385-3-6-3?v=Novus+Biologicals
Average 93 stars, based on 1 article reviews
nbp2 47840af647 rrid ab 3313026 - by Bioz Stars, 2026-07
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NBP2-47840AF647  (novus biologicals)
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novus biologicals NBP2-47840AF647
A , Heatmap of top 100 DEGs in P1_L vs other lesional skin (P2-P5 L) (padj < 0.05, log2FC > ±0.25; Wilcoxon) B , UMAP of cytotoxicity signature in lesional skin (P1-P5). Top: composite score; right/below: four cytotoxic effector genes. C , Cytotoxicity score across all patients (Wilcoxon; P1_L vs P2-P5 L). D , Spatial map of cytotoxicity score in P1_L (middle), underlying H&E histology (left panel) and zoomed view of a representative area showing individual gene expression for selected genes (right). E, Cell type deconvolution (pie charts) of representative area (from D ). F , Fold enrichment of topics in high (≥Q3, top 25%) vs low (<Q3, bottom 75%) cytotoxic regions of P1_L (Wilcoxon with Bejamini Hochberg correction; red dotted line: log2FC =1). G , Correlation between total cytotoxic cell abundance (Tcyto, Cytomono, M1_mac, Neuts) and cytotoxicity score. Points coloured by patient; P1_L (95% CI); ρ = Spearman’s rank. H , Organised_immune topic proportion in P1 L vs P2-P5 L (Wilcoxon). I , Organized immune topic distribution in P1_L across full tissue (left), magnified region (top right), and other topics as pie charts (bottom). J , tertiary lymphoid structures (TLS) hallmark gene expression in representative area from ( I) . K , Multiplex immunofluorescence (IF)of two putative TLS from P1_L showing CD3E+ T cells (top) and <t>CD20+</t> B cells (bottom) in magnified regions. Scale bar, 20µm. **p < 0.01, ****p < 0.0001
Nbp2 47840 Af647, supplied by novus biologicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cd20+antibody+%28igel/pmc12281385-3-0-3?v=novus+biologicals
Average 93 stars, based on 1 article reviews
NBP2-47840AF647 - by Bioz Stars, 2026-07
93/100 stars
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nbp2 47840af647  (Novus Biologicals)
93
Novus Biologicals nbp2 47840af647
A , Heatmap of top 100 DEGs in P1_L vs other lesional skin (P2-P5 L) (padj < 0.05, log2FC > ±0.25; Wilcoxon) B , UMAP of cytotoxicity signature in lesional skin (P1-P5). Top: composite score; right/below: four cytotoxic effector genes. C , Cytotoxicity score across all patients (Wilcoxon; P1_L vs P2-P5 L). D , Spatial map of cytotoxicity score in P1_L (middle), underlying H&E histology (left panel) and zoomed view of a representative area showing individual gene expression for selected genes (right). E, Cell type deconvolution (pie charts) of representative area (from D ). F , Fold enrichment of topics in high (≥Q3, top 25%) vs low (<Q3, bottom 75%) cytotoxic regions of P1_L (Wilcoxon with Bejamini Hochberg correction; red dotted line: log2FC =1). G , Correlation between total cytotoxic cell abundance (Tcyto, Cytomono, M1_mac, Neuts) and cytotoxicity score. Points coloured by patient; P1_L (95% CI); ρ = Spearman’s rank. H , Organised_immune topic proportion in P1 L vs P2-P5 L (Wilcoxon). I , Organized immune topic distribution in P1_L across full tissue (left), magnified region (top right), and other topics as pie charts (bottom). J , tertiary lymphoid structures (TLS) hallmark gene expression in representative area from ( I) . K , Multiplex immunofluorescence (IF)of two putative TLS from P1_L showing CD3E+ T cells (top) and <t>CD20+</t> B cells (bottom) in magnified regions. Scale bar, 20µm. **p < 0.01, ****p < 0.0001
Nbp2 47840af647, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cd20+antibody+%28igel/pmc12281385__mmc1-139-21-19?v=Novus+Biologicals
Average 93 stars, based on 1 article reviews
nbp2 47840af647 - by Bioz Stars, 2026-07
93/100 stars
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Image Search Results


A , Heatmap of top 100 DEGs in P1_L vs other lesional skin (P2-P5 L) (padj < 0.05, log2FC > ±0.25; Wilcoxon) B , UMAP of cytotoxicity signature in lesional skin (P1-P5). Top: composite score; right/below: four cytotoxic effector genes. C , Cytotoxicity score across all patients (Wilcoxon; P1_L vs P2-P5 L). D , Spatial map of cytotoxicity score in P1_L (middle), underlying H&E histology (left panel) and zoomed view of a representative area showing individual gene expression for selected genes (right). E, Cell type deconvolution (pie charts) of representative area (from D ). F , Fold enrichment of topics in high (≥Q3, top 25%) vs low (<Q3, bottom 75%) cytotoxic regions of P1_L (Wilcoxon with Bejamini Hochberg correction; red dotted line: log2FC =1). G , Correlation between total cytotoxic cell abundance (Tcyto, Cytomono, M1_mac, Neuts) and cytotoxicity score. Points coloured by patient; P1_L (95% CI); ρ = Spearman’s rank. H , Organised_immune topic proportion in P1 L vs P2-P5 L (Wilcoxon). I , Organized immune topic distribution in P1_L across full tissue (left), magnified region (top right), and other topics as pie charts (bottom). J , tertiary lymphoid structures (TLS) hallmark gene expression in representative area from ( I) . K , Multiplex immunofluorescence (IF)of two putative TLS from P1_L showing CD3E+ T cells (top) and CD20+ B cells (bottom) in magnified regions. Scale bar, 20µm. **p < 0.01, ****p < 0.0001

Journal: medRxiv

Article Title: Spatial mapping of Ethiopian cutaneous leishmaniasis lesions reveals distinct tissue level immune programs

doi: 10.64898/2026.02.04.26345554

Figure Lengend Snippet: A , Heatmap of top 100 DEGs in P1_L vs other lesional skin (P2-P5 L) (padj < 0.05, log2FC > ±0.25; Wilcoxon) B , UMAP of cytotoxicity signature in lesional skin (P1-P5). Top: composite score; right/below: four cytotoxic effector genes. C , Cytotoxicity score across all patients (Wilcoxon; P1_L vs P2-P5 L). D , Spatial map of cytotoxicity score in P1_L (middle), underlying H&E histology (left panel) and zoomed view of a representative area showing individual gene expression for selected genes (right). E, Cell type deconvolution (pie charts) of representative area (from D ). F , Fold enrichment of topics in high (≥Q3, top 25%) vs low (

Article Snippet: For separate experiment, sections were stained with CD20 (IGEL/773, NBP2-47840C, Novus Biologicals, 1:100, Dylight-650) for B cells and CD3E (CD3-12, ab11089, Abcam, 1:300]) for T cells.

Techniques: Gene Expression, Multiplex Assay, Immunofluorescence